SECUAH 2022 > Sánchez-Esteban etal 2022
dianas | Vol 11 No 1 | marzo 2022 | e202203a
Integrin Linked Kinase Expression In Human Valvular Endothelial Cells Plays A Protective Role In Calcific Aortic Valve Disease
sandrasanchez07@hotmail.com
VII Congreso de Señalización Celular, SECUAH 2022.
14 a 18 de marzo, 2022. Universidad de Alcalá. Alcalá de Henares, Madrid. España.
Keywords: Aortic valve stenosis; Calcification; Endothelial function; Cell signaling
Abstract
Calcific aortic valve disease (CAVD) is the most common valvular heart disease in the aging population.CAVD is a highly active ossification process originated in valvular interstitial cells which differentiate towards an osteoblastic phenotype. However, the role of valvular endothelial cells in CAVD has not been fully explored. We previously demonstrated that ILK expression in vascular endothelium plays an essential cardioprotective role. We hypothesize that endothelial ILK plays a protective role in human valvular endothelial cells osteogenesis.
Citation: Sánchez-Esteban S, Reventún P, Castro M, Cook-Calvete A, Delgado-Marín M, Benito L, Hernández I, López-Menéndez J, Zaragoza C, Saura M (2022) Integrin Linked Kinase Expression In Human Valvular Endothelial Cells Plays A Protective Role In Calcific Aortic Valve Disease. Proceedings of the VII Congreso de Señalización Celular, SECUAH 2022. 14 a 18 de marzo, 2022. Universidad de Alcalá. Alcalá de Henares, Madrid. España. dianas 11 (1): e202203a. ISSN 1886-8746 (electronic) journal.dianas.e202203a. URI http://hdl.handle.net/10017/15181
Copyright: ©2022 Sánchez-Esteban S, Reventún P, Castro M, Cook-Calvete A, Delgado-Marín M, Benito L, Hernández I, López-Menéndez J, Zaragoza C, Saura M. Algunos derechos reservados. This is an open-access work licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. http://creativecommons.org/licenses/by-nc-nd/4.0/
