SECUAH 2018 > Reventún etal 2018

dianas | Vol 7 No 1 | 2018 | e201803

Pathological alterations of cardiac functions and morphology in mice treated with BPA.

P Reventún, S Sánchez, I Cuadrado, R Ramirez, M Saura

reventuntorralba@gmail.com

III Congreso de Señalización Celular, SECUAH 2018.
20-22 de marzo, 2018. Universidad de Alcalá. Alcalá de Henares, Madrid. España.
Sesión

Resumen

Bisphenol A (BPA) is an organic compound used in the manufacturing of polycarbonate plastics. It is presents in various consumer goods and its potential risk to human health has been well characterized. Several epidemiological studies have associated urinary and serum BPA levels in human with various types of cardiovascular diseases including hypertension, heart attack and coronary and peripheral arterial disease. However, molecular mechanisms of BPA toxicity in cardiac functions are widely unknown. To shed light on these processes we treat mice with low doses of BPA orally administrated in drinking water (150ug/ml) for four months. We found important echocardiography and electrocardiography alterations, showing a possible heart failure with diminish of ejection fraction and lost of ventricular contractility. Likewise, heart structure was affected presenting edema, hemorrhagic lesions and clot formations as well as inflammatory alterations. We propose that this process could be developed by the inadequate activation of Unfolding Protein Response as a consequence of BPA exposure and we demonstrated it by the study of the whole pathway. These results suggest an important and relevant toxic effect of BPA in heart physiology.